Two experimental treatments for skin cancer, tailor-made to target a particular patient's tumours, proved safe in small-scale trials, their developers reported Wednesday.
The vaccines also triggered an immune response to tumour cells, they said, although this does not necessarily equate to a cure.
These are the first drug trials in humans with personalised vaccines directed at neoantigens -- molecules, caused by DNA mutations, found in cancer cells. The results of both were published in the journal Nature.
Neoantigens do not appear in normal cells of the human body, making them an ideal target for cancer therapy. Conventional treatments such as chemotherapy kill healthy cells as well as sick ones, with severe side-effects for patients.
"The vaccine was shown to be feasible, safe and consistently immunogenic (producing an immune response) in all patients vaccinated," study co-author Patrick Ott of the Dana-Farber Cancer Institute in Boston told AFP of the first vaccine, dubbed NeoVax.
https://www.afp.com/en/news/2265/tailor ... al-results
Just what the doctor ordered
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