Sampler Did Not Actually Use Native American DNA In Warren Test

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psk836
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Sampler Did Not Actually Use Native American DNA In Warren Test

Post by psk836 » Mon Oct 15, 2018 2:34 pm

https://www.bostonglobe.com/news/politi ... story.html

"Detecting DNA for Native Americans is particularly tricky because there is an absence of Native American DNA available for comparison. This is in part because Native American leaders have asked tribal members not to participate in genetic databases.

“The tribes have felt they have been exploited,” explained Lawrence Brody, a senior investigator with the Medical Genomics and Metabolic Genetics Branch at the National Institutes of Health. “The amount of genetic data that is available from Native Americans is sparse.”

To make up for the dearth of Native American DNA, Bustamante used samples from Mexico, Peru, and Colombia to stand in for Native American. That’s because scientists believe that the groups Americans refer to as Native American came to this land via the Bering Strait about 12,000 years ago and settled in what’s now America but also migrated further south. His report explained that the use of reference populations whose genetic material has been fully sequenced was designed “for maximal accuracy.”'

So, Warren is more likely an illegal immigrant?
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by Pete » Mon Oct 15, 2018 2:38 pm

good Lord what a weak funkin' link. Still close enough for the bedwetters though.

I guess I'm an Indian if I take a dump in the same toilet as Sitting Bull

:toilette2:
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by KC_ » Mon Oct 15, 2018 2:38 pm

psk836 wrote:
Mon Oct 15, 2018 2:34 pm
https://www.bostonglobe.com/news/politi ... story.html

"Detecting DNA for Native Americans is particularly tricky because there is an absence of Native American DNA available for comparison. This is in part because Native American leaders have asked tribal members not to participate in genetic databases.

“The tribes have felt they have been exploited,” explained Lawrence Brody, a senior investigator with the Medical Genomics and Metabolic Genetics Branch at the National Institutes of Health. “The amount of genetic data that is available from Native Americans is sparse.”

To make up for the dearth of Native American DNA, Bustamante used samples from Mexico, Peru, and Colombia to stand in for Native American. That’s because scientists believe that the groups Americans refer to as Native American came to this land via the Bering Strait about 12,000 years ago and settled in what’s now America but also migrated further south. His report explained that the use of reference populations whose genetic material has been fully sequenced was designed “for maximal accuracy.”'

So, Warren is more likely an illegal immigrant?
You gotta love those DNA scientists and their quirky methods. :lo2l:
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by psk836 » Mon Oct 15, 2018 2:42 pm

Pete wrote:
Mon Oct 15, 2018 2:38 pm
good Lord what a weak funkin' link. Still close enough for the bedwetters though.

I guess I'm an Indian if I take a dump in the same toilet as Sitting Bull

:toilette2:
So I guess she is more likely to be related to Che Guevara or Poncho Villa than Geronimo.
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by evilconempire » Mon Oct 15, 2018 2:48 pm

Background Information
The human genome consists of 23 chromosomes containing sequences of 3,234,830,000 DNA bases,
with genetic length of 3,595 centiMorgans. Because individuals receive one set from each parent, they
carry 46 chromosomes, with a total of 6,469,660,000 DNA bases and a total genetic length of 7,190
centiMorgans. (CentiMorgans are a unit of genetic recombination, which is particularly relevant for
ancestry analysis.)

Genetic methods for ancestry determination look at the small fraction of these DNA bases that
commonly vary between individuals. A subset of these variable bases (called genetic markers) had been
genotyped for the test sample. The markers from the test sample were then analyzed using two classes
of methods: global ancestry methods and local ancestry methods.

Global ancestry methods treat each marker as independent, ignoring correlations between neighboring
markers on the DNA strand. Using the observed frequency of each marker across regional reference
populations (e.g. European, African, Native American), global ancestry methods determine the
likelihood for each marker in the sample originating from each population. A probabilistic model is then
applied to estimate the proportion of markers in the test sample originating from each regional
ancestry. Global ancestry methods have the advantage of considering all genotyped markers at once in
the model (more data), but the disadvantage of ignoring local correlations and patterns between
neighboring markers (since each marker is treated as independent). Global ancestry methods thus may
fail to identify contributions to ancestry, evident in chromosomal segments (Alexander et al., 2011).
Local ancestry methods consider short sequences of neighboring markers; each segment has fewer
markers but has greater statistical power to look at ancestry patterns, by searching for similar sequences
of markers amongst the reference populations. Using local ancestry methods one can identify the
ancestral population (European, African, Native American) from which each piece of each chromosome
derived. Our method (RFMix) uses random forests, a highly accurate modern machine learning
algorithm, to identify and match these sequence patterns (Maples et al., 2013). To analyze the longest
Native American ancestry segment in the sample, we used an independent machine learning technique
called principal component analysis (Novembre et al., 2008).

For maximal accuracy, we use reference populations that have been fully sequenced (complete
genomes) rather than references that had been genotyped at only a subset of sites. These samples
come from the 1000 Genomes research project, which sequenced full genomes from individuals around
the world (1000 Genomes Project Consortium, 2012). For Native American references, we used samples
within the 1000 Genomes project of Native American ancestry; these samples come from Mexico, Peru,
and Colombia. (It is not possible to use Native American reference sequences from inside the United
States, since Native American groups within the US have not chosen to participate in recent population
genetics studies.) The 1000 Genomes reference samples come from Nigerian Yoruba individuals (for
Sub-Saharan Africa), Finnish, Tuscan Italian, and Spanish individuals (for Europe), and northern Chinese
individuals for East Asia. (The latter reference was used to test for East Asian regional ancestry, since
that can otherwise be mis-assigned as Native American). In our analysis, an individual with 100%
ancestry assigned to a single population (e.g., European or African) is defined as an “unadmixed”.

We also compared the ancestry segments seen in the sample to 185 reference individuals from Europe
(Great Britain) as well as American individuals from Utah. A few of the Utah individuals have a small
amount of Native American ancestry, and for this reason the standard deviation of Native American
ancestry in the Utah individuals is somewhat higher than in the British samples.
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by psk836 » Mon Oct 15, 2018 2:52 pm

"To make up for the dearth of Native American DNA, Bustamante used samples from Mexico, Peru, and Colombia to stand in for Native American."
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by psk836 » Mon Oct 15, 2018 2:53 pm

I guess we now know why she hand picked this sampler.
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by Pete » Mon Oct 15, 2018 2:55 pm

"....the dearth of Native American DNA..."

so real Native Americans refuse to give yet she freely gave hers to get a better paying job

go figure
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by evilconempire » Mon Oct 15, 2018 2:57 pm

psk836 wrote:
Mon Oct 15, 2018 2:53 pm
I guess we now know why she hand picked this sampler.
Because he was extremely qualified.
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Re: Sampler Did Not Actually Use Native American DNA In Warren Test

Post by evilconempire » Mon Oct 15, 2018 2:58 pm

Pete wrote:
Mon Oct 15, 2018 2:55 pm
"....the dearth of Native American DNA..."

so real Native Americans refuse to give yet she freely gave hers to get a better paying job

go figure
Trumpsters have been squawking about her taking a DNA test and now you're going to berate for doing it.

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